Synthesis and antibacterial evaluation of alkaloid-like phenylfuroacridones.

Autor: Kudryavtsev, T. A., Kudryavtseva, T. N., Melnichenko, V. E., Lamanov, A. Yu., Klimova, L. G.
Předmět:
Zdroj: Russian Chemical Bulletin; Aug2023, Vol. 72 Issue 8, p1953-1956, 4p
Abstrakt: A number of new alkaloid-like phenylfuroacridones were synthesized by cyclization in polyphosphoric acid of 2-, 3 -, 4-(2-oxo-2-phenylethoxy)acridones, which, in turn, were obtained by O-alkylation of the corresponding 2-, 3-, 4-hydroxyacridones with phenacyl bromide. Biological studies showed that phenylfuroacridones exhibited a low antibacterial activity against the test strain Candida albicans. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index