| Autor: |
Subramaniyan, Bharathiraja, Larabee, Jason L., Bodas, Manish, Moore, Andrew R., Burgett, Anthony W. G., Papin, James F., Walters, Matthew S. |
| Předmět: |
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| Zdroj: |
American Journal of Respiratory Cell & Molecular Biology; Sep2023, Vol. 69 Issue 3, p367-370, 6p |
| Abstrakt: |
The article investigate the role of UCHL1 (ubiquitin C-terminal hydrolase 1) in regulating SARS-CoV-2 infection in human airway epithelial cells. It discusses how inhibiting UCHL1 enzymatic activity with LDN-57444 suppresses SARS-CoV-2 replication in a dose-dependent manner. It also explores the impact of UCHL1 overexpression on virus replication and suggests that targeting UCHL1 activity may lead to the development of antiviral compounds. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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