| Autor: |
Salomon, Ophira, Steinberg, David M., Pshithizki, Meirav, Zalel, Yaron, Lerner, Asaf, Rosenberg, Nurit, Achiron, Reuwen |
| Předmět: |
|
| Zdroj: |
Journal of Women's Health (15409996); May2005, Vol. 14 Issue 4, p306-310, 5p, 4 Charts, 2 Graphs |
| Abstrakt: |
Objective: To determine if the presence of prothrombotic polymorphisms, such as factor V G1691A (factor V Leiden) or factor II G20210A, affect the length of secon-dary postpartum bleeding. Methods: We conducted a prospective and blind study that enrolled primiparous healthy women following singleton pregnancy. Whole blood was taken for determining the presence of factor V G1691A or prothrombin G202-10A by PCR and specific restriction enzymes. Results: We enrolled 638 women, of whom 524 had vaginal delivery, 34 had planned cesarean delivery, and 80 had emergency cesarean delivery. Seventy-nine of 524 women with vaginal delivery required vacuum, 19 women needed forceps, and 2 women required both vacuum and forceps. Seventy parturients had prothrombotic polymorphisms: 31 were heterozygote to factor V G1691A, 34 were heterozygote to prothrombin G20210A, and 1 was homozygote for the mutation. Another 4 women had both mutations. Women who gave birth by planned cesarean deliveries bled 4.9 days longer on average than women who gave birth vaginally or had emergency cesarean delivery (p= 0.03), after adjustment for length of pregnancy. The weight of the newborn and the length of the pregnancy affected the duration of bleeding. The presence of prothrom-botic polymorphisms did not affect the duration of postpartum bleeding. Conclusions: The duration of secondary postpartum hemorrhage is related to length of pregnancy, neonate weight, and planned cesarean delivery but is not affected by the presence of factor V G1691A or prothrombin G20210A mutation in the primiparous women. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
