SARS-CoV-2 infection induces epigenetic changes in the LTR69 subfamily of endogenous retroviruses.

Autor: Arora, Ankit, Kolberg, Jan Eric, Srinivasachar Badarinarayan, Smitha, Savytska, Natalia, Munot, Daksha, Müller, Martin, Krchlíková, Veronika, Sauter, Daniel, Bansal, Vikas
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Zdroj: Mobile DNA; 9/4/2023, Vol. 14 Issue 1, p1-9, 9p
Abstrakt: Accumulating evidence suggests that endogenous retroviruses (ERVs) play an important role in the host response to infection and the development of disease. By analyzing ChIP-sequencing data sets, we show that SARS-CoV-2 infection induces H3K27 acetylation of several loci within the LTR69 subfamily of ERVs. Using functional assays, we identified one SARS-CoV-2-activated LTR69 locus, termed Dup69, which exhibits regulatory activity and is responsive to the transcription factors IRF3 and p65/RELA. LTR69_Dup69 is located about 500 bp upstream of a long non-coding RNA gene (ENSG00000289418) and within the PTPRN2 gene encoding a diabetes-associated autoantigen. Both ENSG00000289418 and PTPRN2 showed a significant increase in expression upon SARS-CoV-2 infection. Thus, our study sheds light on the interplay of exogenous with endogenous viruses and helps to understand how ERVs regulate gene expression during infection. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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