| Autor: |
Johnson, Shelsey, Sommer, Natascha, Cox-Flaherty, Katherine, Weissmann, Norbert, Ventetuolo, Corey E., Maron, Bradley A. |
| Předmět: |
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| Zdroj: |
American Journal of Respiratory & Critical Care Medicine; 9/1/2023, Vol. 208 Issue 5, p528-548, 21p |
| Abstrakt: |
Major advances in pulmonary arterial hypertension, pulmonary hypertension (PH) associated with lung disease, and chronic thromboembolic PHcast new light on the pathogeneticmechanisms, epidemiology, diagnostic approach, and therapeutic armamentarium for pulmonary vascular disease. Here, we summarize key basic, translational, and clinical PHreports, emphasizing findings that build on current state-of-the-art research. This review includes cutting-edge progress in translational pulmonary vascular biology, with a guide to the diagnosis of patients in clinical practice, incorporating recent PH definition revisions that continue emphasis on early detection of disease. PHmanagement is reviewed including an overview of the evolving considerations for the approach to treatment of PHin patients with cardiopulmonary comorbidities, as well as a discussion of the groundbreaking sotatercept data for the treatment of pulmonary arterial hypertension. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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