| Autor: |
Maria Pelaez, Julita, Romero Rojas-Ramos, Juliana Cristina, Torquato Domingos, Mouseline, Rabassi de Lima, Marcella, de Carvalho Kraemer, Gabriela, de Andre Cardoso-Demartini, Adriane, Marques Pereira, Rosana, de Lacerda, Luiz, Nesi-França, Suzana |
| Předmět: |
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| Zdroj: |
Jornal de Pediatria; Sep/Oct2023, Vol. 99 Issue 5, p478-484, 7p |
| Abstrakt: |
Objectives: To describe the neurocognitive profile of 458 children with congenital hypothyroidism detected by neonatal screening, followed under the same treatment protocol over 25 years. To correlate estimated full-scale IQ (FSIQ) scores with age at the start of treatment, disease severity, and maternal education. Methods: Observational, analytical, retrospective, and longitudinal cohort study, that evaluated children detected between 1991 and 2014, who underwent at least one psychometric assessment (WPPSI-R and/or WISC-III). Estimated FSIQ scores are described and correlated with prognosis determinants. Results: Median T4 at diagnosis was 2.8 mg/dL (0.0-16.5), the median age at the start of treatment was 18.5 days (3-309). Maternal education (n = 445): 2.7% of illiteracy, 59.8% with basic education. Estimated FSIQ scores were 88.0 (§11.8) in WPPSI-R (age 5.6 § 0.5 years) and 84.1 (§13.0) in WISC-III (age 9.1 § 1.4 years). The intellectual deficit was identified in 11.6%. Correlation between age at the start of treatment and estimated FSIQ was found only in the WPPSI-R test (p = 0.02). Initial T4 and maternal education significantly correlated with estimated FSIQ scores in both tests, with the latter being the most important determining factor. Conclusions: In this large cohort of mainly low socioeconomic status children, most children achieved normal cognitive levels; however, a significant percentage presented with below-average estimated FSIQ scores and intellectual deficits. Maternal education was the main determining factor in cognitive level followed by hypothyroidism severity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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