| Autor: |
Li, Jun, Jiang, Yinghong, Xue, Wei, Liu, Lejiang, Yu, Hua, Zhang, Xuemei, Ye, Xiao, Miao, Jianrong, Liu, Jianling, Chen, Yueen, Lan, Xingbin, Liu, Xiaoqing, Yao, Wensong, Sun, Jianchuan, Zheng, Jing, Xiao, Jianzhong |
| Zdroj: |
Regenerative Medicine; Sep2023, Vol. 18 Issue 9, p695-706, 12p |
| Abstrakt: |
Aim: This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice. Methods: UCBMCs were injected once into the scrotal sheath cavity of elderly mice. Results: The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000). Conclusion: Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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