| Autor: |
Li, Haotian, Zu, Tao, Chen, Ruike, Ba, Ruicheng, Hsu, Yi‐Cheng, Sun, Yi, Zhang, Yi, Wu, Dan |
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| Zdroj: |
Magnetic Resonance in Medicine; Nov2023, Vol. 90 Issue 5, p1969-1978, 10p |
| Abstrakt: |
Purpose: 3D pulse sequences enable high‐resolution acquisition with a high SNR and ideal slice profiles, which, however, is particularly difficult for diffusion MRI (dMRI) due to the additional phase errors from diffusion encoding. Methods: We proposed a twin navigator‐based 3D diffusion‐weighted gradient spin‐echo (GRASE) sequence to correct the phase errors between shots and between odd and even spin echoes for human whole‐brain acquisition. We then compared the SNR of 3D GRASE and 2D simultaneous multi‐slice EPI within the same acquisition time. We further tested the performance of 2D versus 3D acquisition at equivalent SNR on fiber tracking and microstructural mapping, using the diffusion tensor and high‐order fiber orientation density–based metrics. Results: The proposed twin navigator approach removed multi‐shot phase errors to some extent in the whole brain dMRI, and the 2D navigator performed better than the 1D navigator. Comparisons of SNR between the 2D simultaneous multi‐slice EPI and 3D GRASE sequences demonstrated that the SNR of the GRASE sequence was 1.4–1.5‐fold higher than the EPI sequence at an equivalent scan time. More importantly, we found a significantly higher fiber cross‐section in the cerebrospinal tract, as well as richer subcortical fibers (U‐fibers) using the 3D GRASE sequence compared to 2D EPI. Conclusion: The twin navigator‐based 3D diffusion‐weighted‐GRASE sequence minimized the multishot phase error and effectively improved the SNR for whole‐brain dMRI acquisition. We found differences in fiber tracking and microstructural mapping between 2D and 3D acquisitions, possibly due to the different slice profiles. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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