| Autor: |
Gandidzanwa, Sendibitiyosi, Beukes, Natasha, Joseph, Sinelizwi V, Janse Van Vuuren, Arno, Mashazi, Philani, Britton, Jonathan, Kilian, Gareth, Roux, Saartjie, Nyokong, Tebello, Lee, Michael E, Frost, Carminita L, Tshentu, Zenixole R |
| Předmět: |
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| Zdroj: |
Nanotechnology; 11/12/2023, Vol. 34 Issue 46, p1-15, 15p |
| Abstrakt: |
Folate receptor-targeted therapy has excellent prospects for the treatment of breast cancer. A non-toxic concentration of folate-conjugated palladium-based nanoparticles was used to target the overexpressed folate receptor on breast cancer cells. The folate-conjugated nanoparticles were tailored to accumulate selectively in cancer cells relative to normal cells via the folate receptor. The MDA-MB-231, MDA-MB-468, MCF-7 breast cancer cell lines, and MCF-10A normal cell lines were used in the study. Qualitative and quantitative analysis of nanoparticle cellular uptake and accumulation was conducted using transmission electron microscopy and inductively coupled plasma-optical emission spectroscopy. The findings proved that folate-conjugated palladium nanoparticles successfully and preferentially accumulated in breast cancer cells. We conclude that folate-conjugated palladium nanoparticles can be potentially used to target breast cancer cells for radiopharmaceutical applications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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