| Autor: |
Titova, M. A., Alifirova, V. M., Musina, N. F., Nikolaeva, T. N. |
| Zdroj: |
Neurochemical Journal; Sep2023, Vol. 17 Issue 3, p412-417, 6p |
| Abstrakt: |
Abstract—We studied the role of the rs1800629 polymorphism of the TNF-α gene; the rs4149584 polymorphism of the TNFRSF1A gene; and the rs6074022, rs1883832, rs1535045, and rs11086996 polymorphisms of the CD40 gene in the onset, clinical course, and response to treatment in multiple sclerosis (MS) in a group of 152 patients living in Tomsk region. A total of 707 volunteers without autoimmune diseases and pathology of the nervous system were included in the control group. The C allele of the rs6074022 polymorphism of CD40 gene was associated with the risk of MS and contributed to the high rate of disease progression. The T allele of the rs6074022 polymorphism of the CD40 gene showed a significant association with the average rate of disease progression, and the GA genotype of the rs1800629 polymorphism of the TNF-α gene was associated with a higher frequency of MS exacerbation. Other polymorphisms did not demonstrate an association with both the risk of disease, the clinical features and response to treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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