| Autor: |
Kanabrocki, Eugene L., Sothern, Robert B., Messmore, Harry L., Roitman-Johnson, Beatrice, McCormick, James B., Dawson, Susan, Bremner, Fraser W., Third, Jane L. H. C., Nemchausky, Bernard A., Shirazi, Parvez, Scheving, Lawrence E. |
| Předmět: |
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| Zdroj: |
Clinical & Applied Thrombosis/Hemostasis; Jan1999, Vol. 5 Issue 1, p37-42, 6p, 4 Charts, 2 Graphs |
| Abstrakt: |
Circadian (24 h) rhythms of fibrinogen, interleukin-6 (IL-6), and platelet levels were studied in 11 males ages 46 to 72 years. Since there is a known circadian rhythm for fibrinogen and IL-6, we postulated that the peak level (acrophase) of fibrinogen would follow the acrophase of IL-6, based on the fact that IL-6 is the stimulus for fibrinogen production in the liver. Platelet levels were measured to show whether there was any correlation with the IL-6 acrophase because it has been reported that IL-6 affects megakaryocytes and platelets in dogs. We found that the acrophase for IL-6 occurred at 02:03 h and the acrophase for fibrinogen occurred at 09:16 h. Platelet counts peaked at 16:56 h. Thus, there was a positive correlation between IL-6 and fibrinogen acrophases and a negative correlation of each with the acrophase for platelets. The positive linkage of IL-6 with fibrinogen in this study suggests that suppression of IL-6 production would lower those peak fibrinogen levels that occur in the morning in association with arterial ischemic events. This could result in fewer arterial ischemic events, especially in the morning. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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