| Autor: |
Pérez-Arana, Gonzalo-Martín, Díaz-Gómez, Alfredo, Bancalero-de los Reyes, José, Gracia-Romero, Manuel, Ribelles-García, Antonio, Visiedo, Francisco, González-Domínguez, Álvaro, Almorza-Gomar, David, Prada-Oliveira, José-Arturo |
| Předmět: |
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| Zdroj: |
Frontiers in Endocrinology; 2023, p1-9, 9p |
| Abstrakt: |
The biological activity of glucagon has recently been proposed to both stimulate hepatic glucose production and also include a paradoxical insulinotropic effect, which could suggest a new role of glucagon in the pathophysiology type 2 diabetes mellitus (T2DM). An insulinotropic role of glucagon has been observed after bariatric/metabolic surgery that is mediated through the GLP-1 receptor on pancreatic beta cells. This effect appears to be modulated by other members of the proglucagon family, playing a key role in the beneficial effects and complications of bariatric/metabolic surgery. Glucagon serves a dual role after sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). In addition to maintaining blood glucose levels, glucagon exhibits an insulinotropic effect, suggesting that glucagon has a more complex function than simply an "antiinsulin hormone". [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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