| Autor: |
Zafar, Nadiah, Mahmood, Asif, Sarfraz, Rai Muhammad, Ijaz, Hira, Ashraf, Muhammad Umar, Mehr, Sidra |
| Předmět: |
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| Zdroj: |
Polymer Bulletin; Oct2023, Vol. 80 Issue 10, p10939-10971, 33p |
| Abstrakt: |
The research aims to develop cyclophosphamide-β-cyclodextrin complex-loaded hydrogels via free radical polymerization reaction by using hydroxypropyl methylcellulose (HPMC) as polymer, acrylic acid as monomer, ammonium per sulfate as initiator, and ethylene glycol dimethyl acrylate (EGDMA) as crosslinker. Nine formulations (HA1–HA9) were formulated to analyze the influence of process control parameters on cyclophosphamide release profile. Optimized preparation condition was investigated depending on substrate concentration, pH, and temperature. FTIR, DSC, TGA, and XRD were used to evaluate the compatibility of the excipients with cyclophosphamide, thermal stability of hydrogels, nature of pure cyclophosphamide, and drug-loaded hydrogel disks. Results showed that increasing concentration of polymer and monomer enhanced hydrogel swelling. However, increased crosslinker concentration resulted in decreased hydrogel swelling. In-vitro drug release studies showed maximum cyclophosphamide release occurred at pH 7.4. An acute oral toxicity assessment on rabbits revealed that the hydrogels were biocompatible with the biological system. This study proved that HPMC-co-AA (HA6 containing 0.6 gm HPMC, 0.9 gm acrylic acid, and 0.8 gm EGDMA)-based hydrogels can be an ideal candidate for achieving prolonged cyclophosphamide release. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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