Chemical constituents from the stem bark of Albizia julibrissin and their SREBP-1c inhibitory activity.

Autor:	Xian, Meiling, Oh, Mira, Kwak, Hee Jae, Jeong, Hyunjin, Ko, Hyun-Jeong, Kim, Seung Hyun
Předmět:	MEDICINAL plants LIGNANS STEROLS ANIMAL experimentation NON-alcoholic fatty liver disease NUCLEAR magnetic resonance spectroscopy PLANT stems BARK LINOLEIC acid RESEARCH funding MOLECULAR structure LIVER cells CELL lines CARRIER proteins MICE
Zdroj:	Journal of Asian Natural Products Research; Sep2023, Vol. 25 Issue 9, p912-917, 6p
Abstrakt:	One new lignan, julibrissinoside II, along with thirteen known compounds, was isolated from the stem bark of Albizia julibrissin. The structure of julibrissinoside II was determined on the basis of extensive spectroscopic methods, including NMR and CD spectroscopic data. The isolated compounds were tested for their SREBP-1c inhibitory activity at different concentrations using mouse hepatocyte AML12 cell lines. Among them, linoleic acid (2) and 3-O-methylfisetin (4) showed significant SREBP-1c inhibitory activity at the concentration of 100 µM. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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