| Autor: |
Malyshko, V. V., Fedulova, L. V., Sokolov, M. E., Moiseev, A. V., Basov, A. A., Dorohova, A. A., Shashkov, D. I., Dzhimak, S. S. |
| Zdroj: |
Biophysics; Apr2023, Vol. 68 Issue 2, p295-301, 7p |
| Abstrakt: |
Alginates varying in modifying additives (primarily, chitosan) and physical treatment methods are used to design prototypes of innovative wound dressings. The aims of the study were to create a prototype sodium alginate fabric wound dressing with silver nanoparticles (AgNPs) subjected to ten freeze–thaw cycles, to assess its properties, and to evaluate its efficacy in treating the purulent wound process in rats. The original technology of ten freeze–thaw cycles was shown to significantly increase the AgNP amount in the sodium alginate wound dressing, primarily by increasing the amount of AgNPs no larger than 15 nm in diameter, which exert the highest antibacterial activity. The wound dressing with AgNPs reduced the metabolic disturbances in the local function of the nonspecific defense system. On days 3 and 5 after wounding, free radical oxidation indices were more favorable and the levels of antioxidant enzymes (catalase and superoxide dismutase (SOD)) in wound tissue were lower than observed upon application of a wound dressing with AgNPs, but without alginate, or after daily wound debridement without using alginate or AgNPs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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