The effect on plasma corticosteroid levels of the short term topical application of clobetasol propionate.

Autor: Walker, Stuart R., Wilson, Lyn, Fry, Lionel, James, V. H. T.
Předmět:
Zdroj: British Journal of Dermatology; Sep1974, Vol. 91 Issue 3, p339-343, 5p
Abstrakt: Thirty-four patients with skin diseases which necessitated treatment with potent topical steroids at a hospital clinic were studied. All the patients received clobetasol propionate ointment (Dermovate) for a period of 2 weeks and sixteen of the patients continued with their treatment for 4 weeks, during which time their plasma corticosteroid levels were measured. Thirty patients had normal levels throughout the whole period of study (⩾ 6 μg/100 ml) and five patients showed a depressed level at some stage during the investigation. Of six patients who were using a large amount of clobetasol ointment (more than 100 g/week) and who had a significant proportion of their body affected by disease (20-80%), two had lowered plasma corticosteroid levels and in four there was no evidence of adrenal suppression. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index