| Abstrakt: |
In contrast to patients with quantitative vitamin B SB 12 sb deficiency not caused by nitrous oxide, who tend to have more prominent sensory abnormalities, nitrous oxide users often exhibit more pronounced motor dysfunction.[41] How should patients be treated? Other complementary hypotheses to explain the neurotoxicity of nitrous oxide include N-methyl-D-aspartate (NMDA) antagonism,[32],[33] dysregulation of cytokines and growth factors that regulate myelin integrity,[34] and hypoxia resulting from prolonged, heavy nitrous oxide use.[35]-[37] What are the consequences of chronic nitrous oxide use? Although no Canadian agencies track nitrous oxide use, evidence of substantial recreational use is apparent in Toronto and Montréal.[9],[10] Large quantities of nitrous oxide and associated paraphernalia are easily ordered online, with rapid shipping to major cities.[11] The drug's popularity relates in part to its low cost, ease of access and perception of safety relative to other drugs.[12],[13] Although acute, heavy use of nitrous oxide can occasionally cause death by asphyxiation,[14],[15] isolated, short-term use rarely leads to serious complications.[16] Regular inhalation, however, can have serious and even devastating neurologic consequences. [Extracted from the article] |
