| Autor: |
Moon, Rebecca J., D'Angelo, Stefania, Holroyd, Christopher R., Crozier, Sarah R., Godfrey, Keith M., Davies, Justin H., Cooper, Cyrus, Harvey, Nicholas C. |
| Předmět: |
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| Zdroj: |
Journal of Clinical Endocrinology & Metabolism; Sep2023, Vol. 108 Issue 9, pe726-e733, 8p |
| Abstrakt: |
Context: Children born to parents who are overweight or obese have a high risk of adult obesity, but it is unclear if transgenerational associations relating to unfavorable body composition differ by parent. Objective: To examine differential mother-offspring and father-offspring associations in body composition in early childhood. Methods: A total of 240 mother-father-offspring trios from a prospective UK population-based pre-birth cohort (Southampton Women's Survey) were included for anthropometry and dual-energy x-ray absorptiometry assessment of whole-body-less-head body composition in the offspring at 3 different ages (4, 6-7, and 8-9 years) and in the mother and father at the 8- to 9-year offspring visit. Associations were assessed using linear regression adjusting for the other parent. Results: Positive associations between mother-daughter body mass index (BMI) and fat mass were observed at ages 6 to 7 (BMI: β = .29 SD/SD, 95% CI = .10, .48; fat mass β = .27 SD/SD, 95% CI = .05, .48) and 8 to 9 years (BMI: β = .33 SD/SD, 95% CI = .13, .54; fat mass β = .31 SD/SD, 95% CI = .12, .49), with similar associations at age 4 years but bounding the 95% CI. The mother-son, father-son, and father-daughter associations for BMI and fat mass were weaker at each of the ages studied. Conclusion: A strong association between the fat mass of mothers and their daughters but not their sons was observed. In contrast, fatheroffspring body composition associations were not evident. The dimorphic parent-offspring effects suggest particular attention should be given to early prevention of unfavorable body composition in girls born to mothers with excess adiposity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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