Multiomics of three hematological malignancies in a patient reveal their origin from clonal hematopoietic stem cells.

Autor: Mayeur, Sylvain, Molitor, Anne, Miguet, Laurent, Rigolot, Lucie, Naegely, Lydie, Stemmelen, Tristan, Meyer, Sébastien, Toussaint, Elise, Vallat, Laurent, Eischen, Alice, Chenard, Marie-Pierre, Tavian, Manuela, Bahram, Seiamak, Carapito, Raphael, Nicolae, Alina
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Zdroj: Blood Cancer Journal; 8/9/2023, Vol. 13 Issue 1, p1-4, 4p
Abstrakt: It was involved by a CD30+ mature T cell lymphoma with cytotoxic phenotype consistent with ALK negative anaplastic large T cell lymphoma (ALK- ALCL) based on cytological assessment, immunophenotyping and PCR analysis of T-cell receptor gamma gene ( I TRG i ) rearrangements (Supplementary Fig. An excisional LN biopsy showed beside ALK- ALCL persistence, a diffuse large B-cell lymphoma (DLBCL-NOS) that was further confirmed by a monoclonal immunoglobulin kappa locus ( I IGK i ) rearrangement and an acute myeloid leukemia with monoblastic/monocytic differentiation (AML-M5) (Fig. 8389176 15 Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S. Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas. So far, CH involvement in the pathobiology of cytotoxic T-cell neoplasms has been only suspected, with recurrent I TET2 i and I DNMT3A i mutations documented in nodal cytotoxic peripheral T-cell lymphomas (TCL), some with history of B-cell lymphomas or MDS [[11]]. [Extracted from the article]
Databáze: Complementary Index
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