Donor-derived CD19-targeted chimeric antigen receptor T cells in adult transplant recipients with relapsed/refractory acute lymphoblastic leukemia.

Autor:	Aldoss, Ibrahim, Khaled, Samer K., Wang, Yan, Wang, Xiuli, Palmer, Joycelynne, Clark, Mary C., Wagner, Jamie R., Paul, Jinny, Vyas, Vibhuti, Brown, Christine E., Forman, Stephen J.
Předmět:	STEM cell transplantation HEMATOPOIETIC stem cell transplantation CHIMERIC antigen receptors LYMPHOBLASTIC leukemia ACUTE leukemia BLAST injuries
Zdroj:	Blood Cancer Journal; 7/12/2023, Vol. 13 Issue 1, p1-4, 4p
Abstrakt:	The refractory patient who received a donor-derived product had I KMT2A i rearrangement and experienced early marrow and extramedullary CD19-negative disease progression shortly after T cells infusion. We did not observe unexpected toxicities in patients who received donor-derived CAR T cells, which was anticipated considering that donor CD3 chimerism was high in most patients at the time of enrollment. The orange curve represents patients who received donor-derived CAR T cells, and the blue curve represents patients who received autologous CAR T cells. [Extracted from the article]
Databáze:	Complementary Index
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