| Autor: |
Al-Saleh, Iman, El-Doush, Inaam, Shinwari, Neptune, Al-Baradei, Raid, Khogali, Fathia, Al-Amodi, Mona |
| Předmět: |
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| Zdroj: |
Cutaneous & Ocular Toxicology; 2005, Vol. 24 Issue 1, p11-29, 19p, 7 Black and White Photographs, 3 Charts, 1 Graph |
| Abstrakt: |
Fair & Lovely is an over-the-counter skin-lightening cream sold widely in Saudi markets. Its mercury content is 0.304±0.316 µg/g, in the range of 0.102 to 0.775 µg/g. This study was designed to evaluate its toxic effects on mice. The cream was applied on mice for a period of 1 month at different intervals. Mercury levels were measured in the liver, kidney, and brain tissue samples of a total of 75 adult female CD1 mice by Atomic Absorption Spectrophotometer coupled to a Vapor Generator Accessory. The mean mercury concentrations in the tissues of the treated mice were 0.193±0.319 µg/g; whereas for the control group, it was 0.041 µg/g±0.041µg/g. While the kidney was found to have the highest mercury content, the brain was found to have the lowest content. Treated mice showed a significant reduction in body weight. Marked histological changes were clearly noted in the kidney and, to a lesser extent, in the brain and liver. These results indicate that although Fair & Lovely mercury content is less than the U.S. Food and Drug Administration (FDA) permissible limits histopathological changes in the brain, kidney, and liver tissues are evidence of its possible toxicity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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