Significance of myocardial injury on in hospital clinical outcomes of in-hospital and COVID-19 patients.

Autor:	Vyas, Pooja, Mishra, Ashish, Parwani, Kunal, Patel, Iva, Dhokia, Dhara, Amin, Trishul, Shah, Prarthi, Boob, Tanmay, Parikh, Rujuta, Dake, Radhakishan, Banker, Khamir
Předmět:	EVALUATION of medical care TROPONIN CARDIOVASCULAR diseases risk factors BIOMARKERS LENGTH of stay in hospitals COVID-19 CONFIDENCE intervals MYOCARDIAL injury RETROSPECTIVE studies ACQUISITION of data CALCITONIN HOSPITAL mortality HOSPITAL care MEDICAL records DESCRIPTIVE statistics RESEARCH funding LOGISTIC regression analysis DISEASE risk factors EVALUATION
Zdroj:	Journal of Cardiovascular & Thoracic Research; Jun2023, Vol. 15 Issue 2, p93-97, 5p
Abstrakt:	Introduction: Acute Myocardial injury defined by increased troponin I level is associated with poor in-hospital outcomes and cardiovascular complications in patients with COVID-19. The current study was designed to determine the implications and clinical outcome of myocardial injury in COVID-19. Methods: This retrospective study included hospitalized COVID-19 patients. Myocardial injury was defined by high sensitivity Troponin I (hs-TNI) ≥ 26ng/l. Cardiac biomarkers, inflammatory markers and clinical data were systemically collected and analyzed. Hazard ratio for in-hospital mortality and logistic regression for predictors of acute myocardial injury were analyzed. Results: Of the 1821 total patients with COVID-19, 293(16.09%) patients died and 1528 (83.91%) patients survived. Patients who died had significantly higher association with presence of cardiovascular risk factors, severe CTSS ( CT severity score ) and myocardial injury as compared to survived group. 628 (34.5%) patients had evidence of myocardial injury and they had statistically significant association with cardiovascular risk factors, in-hospital mortality, procalcitonin; higher hospital, and ICCU stay. We found significant hazard ratio of diabetes (HR = 2.66, (CI:1.65-4.29)), Severe CT score (HR = 2.81, (CI:1.74-4.52)), hs-TNI ≥ 26 ng/l (HR = 4.68, (CI:3.81-5.76)) for mortality. Severe CTSS score (OR = 1.95, CI: 1.18-3.23, P = 0.01) and prior CVD history (OR = 1.65, CI:1.00-2.73, P = 0.05) were found significant predictors of myocardial injury in regression analysis. Conclusion: Almost one third of hospitalized patients had evidence of acute myocardial injury during hospitalization. Acute myocardial injury is associated with higher hospital and ICCU stay, mortality, higher in-hospital infection which indicates more severe disease and the poor in-hospital outcomes. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu