The relationship of myocardial and liver T2* values with cardiac function and laboratory findings in transfusion-dependent thalassemia major patients: A retrospective cardiac MRI study.
| Autor: | Abdi, Sepideh, Taheri, Negar, Haghighi, Fatemeh Zahedi, Khaki, Mahya, Najafi, Homa, Hemmati Komasi, Mohammad Mehdi, Hassani, Behrooz |
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| Předmět: |
CLINICAL pathology
LEFT heart ventricle CARDIOVASCULAR diseases risk factors CONFIDENCE intervals CARDIOMYOPATHIES BLOOD transfusion RIGHT heart ventricle MAGNETIC resonance imaging RETROSPECTIVE studies RISK assessment VENTRICULAR dysfunction CARDIAC output CHI-squared test DESCRIPTIVE statistics HEART physiology IRON overload SOCIODEMOGRAPHIC factors BETA-Thalassemia POISSON distribution IRON compounds DISEASE risk factors DISEASE complications |
| Zdroj: | Journal of Cardiovascular & Thoracic Research; Jun2023, Vol. 15 Issue 2, p86-92, 7p |
| Abstrakt: | Introduction: Cardiac complications are the leading cause of death in thalassemia patients. It is assumed that progressive iron accumulation results in myocyte damage. Myocardial T2* measurement by cardiac MRI quantifies iron overload. We aimed to study the association between left and right ventricular (LV and RV) function and iron deposition estimation by cardiac MRI T2* in a sample of Iranian patients. Methods: Cardiac MRI exams of 118 transfusion-dependent thalassemia major patients were evaluated retrospectively. Biventricular function and volume and myocardial and liver T2* values were measured. The demographic and lab data were registered. Poisson and chisquare regression analyses investigated the correlation between the T2* value and ventricular dysfunction. Results: The study participants' mean (SD) age was 32.7y (9.02), and 47.46% were female. Forty-nine cases (41.52%) revealed at least uni-ventricular dysfunction. LV dysfunction was noted in 20 cases, whereas 47 patients revealed RV dysfunction. The risk of LV dysfunction was 5.3-fold higher in patients with cardiac T2* value less than 10msec (RR = 5.3, 95% CI = 1.6, 17.1, P < 0.05). No association was found between age, liver T2* value, serum ferritin level, and chelation therapy with the risk of LV and RV dysfunction. Conclusion: Cardiac MRI T2* measure is a good indicator of LV dysfunction. Moreover, MRI parameters, especially RV functional measures, may have a substantial role in patient management. Therefore, cardiac MRI should be included in beta-thalassemia patients' management strategies. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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