| Autor: |
Francuz, Jovana, Djokić, Sanja, Popsavin, Mirjana, Rodić, Marko V., Kojić, Vesna, Krüger, Biljana, Popsavin, Velimir |
| Předmět: |
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| Zdroj: |
Synlett; Sep2023, Vol. 34 Issue 14, p1699-1703, 5p |
| Abstrakt: |
Keywords: protulactone A; natural products; bicyclic lactones; medicinal chemistry; structure-activity relationship EN protulactone A natural products bicyclic lactones medicinal chemistry structure-activity relationship 1699 1703 5 08/18/23 20230901 NES 230901 Graph Fungi found in marine environments are an interesting source of biologically active compounds. This new approach also started from d -galactose, but instead of building the lactone ring at the beginning of the synthesis, we decided to build the rest of the molecule in the initial steps and to introduce the lactone ring in the final steps of the synthesis. [2] These two natural products were named protulactones A and B. The first total synthesis of (+)-protulactone A ( B PLA b ; Figure 1), the assignment of its configuration, and a preliminary study of its antiproliferative activity were described by the Gracza group in 2017. Protulactone A, natural products, bicyclic lactones, medicinal chemistry, structure-activity relationship. [Extracted from the article] |
| Databáze: |
Complementary Index |
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