One-pot Biginelli synthesis of novel series of 2-oxo/thioxo/imino-1,2,3,4-tetrahydropyrimidine based on 4-hydroxy-2-pyridone.

Autor:	Kamali, Mahmood, Mohammadzadeh, Saeedeh
Zdroj:	Chemical Papers; Sep2023, Vol. 77 Issue 9, p4943-4952, 10p
Abstrakt:	An efficient multicomponent reaction was developed to synthesis of a novel series of (±)-7-methyl-4-aryl-4,6-dihydropyrido[4,3-d]pyrimidine-2,5(1H,3H)-dione/thione/imine from bio-based 4-hydroxy-6-methylpyridine-2-ones, aromatic aldehydes and urea/thiourea/guanidine in the presence of ZnCl2.2H2O in ethanol at 70 °C. Mild conditions as well as the operational simplicity, easy work up, environmentally friendly are the most advantages of this multicomponent for synthesis of potentially bioactive new products. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink