| Abstrakt: |
Background and Aim: Organophosphate (OP) insecticides are important compounds as the most probable common cause of acute poisonings in developing countries. OP intoxication often presents as medical emergencies, and its related morbidity and mortality have not decreased despite major advances in critical care. The present study was conducted to find the incidence of increased levels of serum amylase and serum lipase in OPC poisoning and to identify the relation with prognosis and clinical outcome, out of which one outcome was acute pancreatitis. Material and Methods: The study was conducted at department of General Medicine, Tertiary care institute of Gujarat among the patients suffering from acute Organophosphate poisoning and admitted in emergency/ICU/medicine ward within 24 hours of intoxication event. This was an observational study conducted for the duration of 2 year with sample size of 85 patients out of which only 60 patients fulfill the inclusion and exclusion criteria. Patients were divided in 3 groups as mild, moderate and severe using q SOFA score at the time of admission. Results: Mean serum amylase level values in various q SOFA categories (0, 1, 2 and 3) were 65.03, 81.95, 118.8 and 330.78 IU/l respectively with p value < 0.001 and that of mean serum lipase level values were 41.45, 44.2, 38.9 and 115.69 IU/l respectively with p value 0.05. Serum amylase levels were positively correlated with duration of ICU stay and were better predictor for acute pancreatitis. Conclusion: Organophosphate poisoning is associated with multiple complications, including acute pancreatitis. The study found that levels of serum amylase & lipase were increased in statistically significant number of cases of acute organophosphate poisoning. [ABSTRACT FROM AUTHOR] |
