Ethyl 5-isopropoxy-4-methyl-β-carbo-line-3-carboxylate: structural determinants of benzodiazepine-receptor antagonism.

Autor: Camerman, Arthur, Mastropaolo, Donald, HempeI, Andrew, Camerman, Norman
Předmět:
Zdroj: Acta Crystallographica: Section C (Wiley-Blackwell); Apr2005, Vol. 61 Issue 4, po265-o266, 2p
Abstrakt: Molecules of the title compound, C18H20N2O3, are linked into ribbons by N—H···O and N—H···N hydrogen bonds. Stereochemical comparison with Ro 15–1788 (viz. ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]-benzodiazepine-3-carboxylate) has identified three electro-negative N and O atoms in the molecule as features likely to be responsible for its activity as a benzodiazepine-receptor antagonist. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index