| Autor: |
Kujala, Johanna, Wester, Niklas, Lohela, Terhi J., Kurkela, Mika, Backman, Janne T., Mikladal, Björn, Laurila, Tomi, Koskinen, Jari, Lilius, Tuomas O., Kalso, Eija A. |
| Předmět: |
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| Zdroj: |
British Journal of Clinical Pharmacology; Sep2023, Vol. 89 Issue 9, p2933-2938, 6p |
| Abstrakt: |
Aims: Measuring venous plasma paracetamol concentrations is time‐ and resource‐consuming. We aimed to validate a novel electrochemical point‐of‐care (POC) assay for rapid paracetamol concentration determinations. Methods: Twelve healthy volunteers received 1 g oral paracetamol, and its concentrations were analysed 10 times over 12 h for capillary whole blood (POC), venous plasma (high‐performance liquid chromatography tandem mass spectrometry (HPLC‐MS/MS)), and dried capillary blood (HPLC‐MS/MS). Results: At concentrations >30 μM, POC showed upward biases of 20% (95% limits of agreement [LOA] −22 to 62) and 7% (95% LOA −23 to 38) compared with venous plasma and capillary blood HPLC‐MS/MS, respectively. There were no significant differences between mean concentrations for the paracetamol elimination phase. Conclusions: Upward biases in POC compared with venous plasma HPLC‐MS/MS were likely due to higher paracetamol concentrations in capillary blood than in venous plasma and to faulty individual sensors. The novel POC method is a promising tool for paracetamol concentration analysis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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