| Autor: |
Kumar, Balagani Pavan, Muthuswamy, Ragunathan, Krishna, Konda V. V. S., Meena, Mukesh Kumar, Radha, Anu, Ranjan, Rajeev, Kumar, Sanjeev, Suman, Abhishek |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2023, Vol. 14 Issue 6, p2309-2321, 13p |
| Abstrakt: |
Background: Commiphoracaudatais a traditional medicinal plant which having various medicinal activities but the present research work was focussed on the wound healing activity. The leaves were extracted using continuous hot percolation method. Based on the phytochemical studies, the ethanolic extract was selected for the preparation of herbal tablet. Direct compression was done by making eight batches [F1-F8] of herbal tablets. The pre and post compression studies were investigated for the developed formulation to select optimized one. Aim and objective: The current investigation of the present research is to formulate and develop the herbal tablet from the ethanolic leaf extract of medicinal plant Commiphoracaudata(Wight &Arn.) Engl.and to evaluate the in vitro wound healing studies. Materials and methods: Petroleum ether, Chloroform, Acetone, Ethanol, HPMC, Carbopol, Starch, Lactose monohydrate, Crospovidone, Mannitol, Magnesium stearate, Disodium hydrogen phosphate, Potassium dihydrogen phosphate phosphate which are used for the extraction process and formulation and evaluation of the herbal tablet to analyse the wound healing studies. Result: From this formulation F7 shows the better results than the rest of other formulations and it was subjected for the fibroblast cell line studies(3T3-CCL92) resulted in a significant increase in the percentage from 34.7-53.29% and the dose-response curve produced to be linear which conform the wound healing activity. Then the formulation F7 were carried out for short term accelerated stability studies for 3 months which shows negligible changes. Conclusion: the herbal tablet used for the treatment of wound healing activity as a traditional system of medicine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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