| Autor: |
Perrone, Alina E., Pinillo, Mariana, Rial, Marcela S., Fernández, Marisa, Milduberger, Natalia, González, Carolina, Bustos, Patricia L., Fichera, Laura E., Laucella, Susana A., Albareda, María Cecilia, Bua, Jacqueline |
| Předmět: |
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| Zdroj: |
International Journal of Molecular Sciences; Aug2023, Vol. 24 Issue 15, p11875, 13p |
| Abstrakt: |
Cyclophilins (CyPs) are a family of enzymes involved in protein folding. Trypanosoma cruzi, the causative agent of Chagas disease, has a 19-kDa cyclophilin, TcCyP19, that was found to be secreted in parasite stages of the CL Brener clone and recognized by sera from T. cruzi-infected mice and patients. The levels of specific antibodies against TcCyP19 in T. cruzi-infected mice and subjects before and after drug treatment were measured by an in-house enzyme linked immunosorbent assay (ELISA). Mice in the acute and chronic phase of infection, with successful trypanocidal treatments, showed significantly lower anti-TcCyP19 antibody levels than untreated mice. In children and adults chronically infected with T. cruzi, a significant decrease in the anti-TcCyP19 titers was observed after 12 months of etiological treatment. This decrease was maintained in adult chronic patients followed-up 30–38 months post-treatment. These results encourage further studies on TcCyP19 as an early biomarker of trypanocidal treatment efficiency. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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