Expression of pyroptosis-related genes are correlated with immune microenvironment and predict prognosis in ESCA.

Autor: Shi, Youmeng, Yang, Qiuxing, Tai, Guomei, Chen, Xudong
Předmět:
Zdroj: Journal of Cancer Research & Clinical Oncology; Sep2023, Vol. 149 Issue 12, p10701-10713, 13p
Abstrakt: Objectives: Pyroptosis-related genes (PRGs) are abnormally expressed in a variety of gastrointestinal tumors, this study aimed to investigate the role of pyroptosis genes in assessing the prognosis of esophageal cancer (ESCA). Methods: Through consensus clustering, we identified two subtypes associated with PRGs. After Lasso regression and multivariate Cox regression analysis, a polygenic signature based on six prognostic PRGS was constructed. Afterwards, we combined the risk score with clinical predictors to construct and validate a PRGs-associated ESCA prognostic model. Results: Through analysis, we Successfully constructed and validated a PRGs-associated ESCA prognostic model that predicts ESCA survival and correlates with the tumor immune microenvironment. Conclusion: Based on PRGs features, we established a new ESCA hierarchical model. This model has important clinical implications for ESCA patients, both in terms of assessing prognosis and in terms of targeted and immunotherapy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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