| Abstrakt: |
The aim of the present study was to determine the effect of the species on the toxicokinetics of cyanide and its main metabolite, thiocyanate. Forty-two rats, six pigs and six goats were dosed orally with 3.0 mg KCN/kg body weight, and cyanide and thiocyanate concentrations in blood were measured within 24 h. After the single oral dose, KCN was rapidly absorbed by rats and goats, with a time of peak concentration (Tmax) of 15 min. The maximum plasma concentration (Cmax) of cyanide was observed in goats (93.5 µmol/l), whereas the Cmax of thiocyanate was higher in rats (58.1 µmol/l). The elimination half-life (t1/2) and volume of distribution (Vdarea) of both cyanide and thiocyanate were higher in goats (1.28 and 13.9 h, and 0.41 and 1.76 l/kg, respectively). Whereas the area under the curve (AUC) of cyanide was significantly higher in goats (234.6 µmol.l/h), the AUC of thiocyanate was higher in rats (846.5 µmol.l/h). In conclusion, the results of the present study support the hypothesis that the metabolism of cyanide and its main metabolite, thiocyanate, is species-linked, with the goat being more sensitive to the toxic effects of cyanide/thiocyanate. [ABSTRACT FROM AUTHOR] |
Full text from SpringerLink