An upstream deletion polymorphism within the goat Period circadian regulator 1 (PER1) gene was associated with growth traits.

Autor: Zhang, Taiyuan, Liu, Modian, Yang, Yuta, Wang, Ke, Zhao, Haiyu, Pan, Chuanying
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Zdroj: Animal Biotechnology; 2023, Vol. 34 Issue 4, p819-824, 6p
Abstrakt: The Period circadian regulator (PER) gene family, including PER1, PER2 and PER3, codes transcriptional repressors which could accurately control biological rhythms. PER1/2 gene was proved to be associated with bone mass and PER1 gene was associated with insulin-like growth factor binding proteins 3 (IGFBP3) levels in serum. However, it was few studies reported genetic effects of PER gene on growth traits at the individual level. In this study, we identified the potential insertion/deletion (indel) loci in PER1/2/3 gene, and then explored the relationship between goat growth traits and the frequency of genotype in Shaanbei white cashmere goats (n = 827). As a result, a 9 bp indel within PER1 gene (g.27528003-27528011 del.TGCTGCTGC; rs642467689) was identified using molecular biology techniques. In addition, there existed significant correlation between the 9 bp indel and body height, height at hip cross, chest depth, body length index and cannon circumference index of goats. These results suggested that the 9 bp indel variation in PER1 gene was associated with goat growth traits, providing the theoretical basic for the role of PER1 gene in goat breeding. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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