| Autor: |
Ruifang Li-Gao, Wakil, Salma M., Meyer, Brian F., Dzimiri, Nduna, MookKanamori, Dennis O. |
| Zdroj: |
Physiological Genomics; Apr2018, Vol. 50 Issue 4, p1-10, 10p |
| Abstrakt: |
Over 120 type 2 diabetes (T2D) loci have been identified from genome-wide association analysis (GWAS), mainly from Caucasian populations. Very limited knowledge is available on the Saudi Arabian population. In this study, 122 previously reported T2D related variants from 84 loci were examined in a Saudi Arabian cohort of 1,578 individuals (659 T2D cases and 919 controls). Eleven SNPs corresponding to 9 independent loci had a p-value <0.05. If a more stringent Bonferroni threshold of p=4.1×10-4 (=0.05/122) was applied, none of the SNPs would have reached the significance level. Nine of the SNPs with a p-value <0.05 showed similar odds ratios as previously described, but rs11605924 (CRY2) and rs9470794 (ZFAND3) were in the opposite direction. This study demonstrates the importance of large-scale GWAS studies in the Saudi Arabian population to identify ethnicity-specific disease-associated variants. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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