Magnetic MOF‐199‐Catalyzed Synthesis of Benzo[4,5]imidazo[1,2‐f]phenanthridines and Their Analogues by Tandem C(sp2)−C Coupling and Cyclization Followed by Aromatization.

Autor:	Kim, Min Jeong, Lee, Seong Weon, Dao, Pham Duy Quang, Cho, Chan Sik
Předmět:	PHENANTHRIDINE AROMATIZATION RING formation (Chemistry) QUINOLINE BENZIMIDAZOLES COUPLING reactions (Chemistry)
Zdroj:	ChemistrySelect; 8/4/2023, Vol. 8 Issue 29, p1-6, 6p
Abstrakt:	Treatment of 2‐(2‐bromoaryl)‐ and 2‐(2‐bromovinyl)benzimidazoles with cyclohexane‐1,3‐diones in DMF in the presence of reusable Fe3O4@SiO2@MOF‐199 along with L‐proline and Cs2CO3 afforded 2,3‐dihydrobenzo[4,5]imidazo[1,2‐f]phenanthridin‐4(1H)‐ones and 2,3‐dihydrobenzo[4,5]imidazo[1,2‐a]quinolin‐4(1H)‐ones, respectively, in moderate to good yields. Such C(sp2)−C coupled and cyclized scaffolds were aromatized to benzo[4,5]imidazo[1,2‐f]phenanthridines and benzo[4,5]imidazo[1,2‐a]quinolines in good yields by a one‐pot sequential treatment with NaBH4, POCl3/pyridine, and DDQ. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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