Amyloid peptide hydrogels via formation of coordination polymers with Ag+ by its core peptide equipped with a C-cysteine.

Autor:	Wang, Qian, Zhou, Fu-Peng, Tao, Dan-Dan, Wei, Jin-Hong, Cai, Rui, Jiang, Yun-Bao
Předmět:	PEPTIDES C-terminal residues AMYLOID AMYLOID beta-protein
Zdroj:	Chemical Communications; 8/14/2023, Vol. 59 Issue 63, p9599-9602, 4p
Abstrakt:	We report that the core sequence of amyloid β (Aβ) peptide, KLVFF, when equipped with a C-terminal cysteine residue, exhibited an extremely low minimum hydrogelation concentration of 0.05 wt% in the presence of Ag+ in pH 5 buffer, with this concentration 2 orders of magnitude lower than that of the pentapeptide itself. The CD signal of the Ag+- L -KLVFFC hydrogel was observed to be sensitive to the early-stage aggregation of amyloid β peptide. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu