| Autor: |
Shcherbak, N. S., Suchkova, I. O., Patkin, E. L., Voznyuk, I. A. |
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| Zdroj: |
Neuroscience & Behavioral Physiology; May2023, Vol. 53 Issue 4, p489-495, 7p |
| Abstrakt: |
The enrichment of angioneurology with fundamental achievements is leading to an understanding of new important aspects of the pathogenesis of cerebral ischemia. Knowledge of the epigenetic mechanisms of the development of stroke is becoming increasingly relevant, particularly DNA methylation, which makes a significant contribution to brain injury. This review analyzes animal studies demonstrating that there is a relationship between DNA methylation and cerebral ischemia. A literature search using keywords identified 282 articles in the PubMed database of relevance to this topic. Of these publications, eight addressed genome-wide DNA methylation and six reported results on the DNA methylation of candidate genes in experimental cerebral ischemia. The study results showed that methylation of DNA in the brain in animals is associated with the development of ischemic stroke and may have some role in a number of pathogenetic mechanisms. Thus, two studies found decreases in DNA methylation in two genes in ischemic brain tissues, while four studies found eight genes in which methylation, on the contrary, increased after ischemic stroke. Published data suggest that assessment of the level of DNA methylation in stroke is a promising biomarker for seeking and improving pharmacological and non-pharmacological methods of limiting brain injury in ischemic and reperfusion damage at the stages of preclinical and clinical studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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