Production assessment of 195mPt in Tehran research reactor.

Autor: Vosoughi, Sara, Rovias, Mohammad Reza Aboudzadeh, Rahiminezhad, Ali, Novin, Fatemeh Bolouri, Yousefi, Kamran, Sardjono, Yohannes
Předmět:
Zdroj: Journal of Radioanalytical & Nuclear Chemistry; Aug2023, Vol. 332 Issue 8, p2989-2994, 6p, 1 Color Photograph, 1 Diagram, 2 Charts, 2 Graphs
Abstrakt: Platinum compounds are the main chemotherapeutic agents used in cancer treatment. 195mPt is a promising theranostic radionuclide for targeted radionuclide therapy. This study presents 195mPt production through neutron activation of natural Platinum target in Tehran Research Reactor. Theoretical production yield of 195mPt was calculated through simultaneous solution of differential equations of decay chains, and also simulation with MCNPX. Theoretical results were compared with experimental values. Moreover, liquid–liquid extraction using ethyl acetate was used for chemical separation. The results showed a good agreement between the experimental and theoretical values. In addition, high separation efficiency (> 99%) was achieved via solvent extraction separation. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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