| Autor: |
Heinrich, Niels Søndergaard, Pedersen, Rune Ploegstra, Vestergaard, Mark Bitsch, Lindberg, Ulrich, Andersen, Ulrik Bjørn, Haddock, Bryan, Hansen, Tine Willum, Fornoni, Alessia, Larsson, Henrik Bo Wiberg, Rossing, Peter |
| Předmět: |
|
| Zdroj: |
Diabetes, Obesity & Metabolism; Sep2023, Vol. 25 Issue 9, p2605-2615, 11p |
| Abstrakt: |
Aim: To investigate the effects of ezetimibe on the urine albumin creatinine ratio (UACR) and kidney parenchyma fat content (kidney‐PF) in individuals with type 2 diabetes (T2D) and early chronic kidney disease. Materials and Methods: A randomized, double‐blind, placebo‐controlled study of ezetimibe 10 mg once daily for 16 weeks in individuals with T2D and a UACR of 30 mg/g or higher was conducted. Kidney‐PF was assessed with magnetic resonance spectroscopy. Geometric mean changes from baseline were derived from linear regressions. Results: A total of 49 participants were randomized to ezetimibe (n = 25) or placebo (n = 24). Overall, mean ± standard deviation age was 67 ± 7 years, body mass index was 31 ± 4 kg/m2 and the proportion of men was 84%. The mean estimated glomerular filtration rate was 76 ± 22 mL/min/1.73m2 and median (first‐third quartile) UACR was 95 (41‐297) mg/g. Median kidney‐PF was 1.0% (0.3%‐2.1%). Compared with placebo, ezetimibe did not significantly reduce UACR (mean [95% confidence interval] change: −3% [−28%‐31%]) or kidney‐PF (mean change: −38% [−66%‐14%]). In participants with baseline kidney‐PF above the median, ezetimibe reduced kidney‐PF significantly (mean change: −60% [−84%‐−3%]) compared with placebo, while the reduction in UACR was not significant (mean change: −28% [−54%‐15%]). Conclusions: Ezetimibe did not reduce the UACR or kidney‐PF on top of modern T2D management. However, kidney‐PF was reduced with ezetimibe in participants with high baseline kidney‐PF. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text