| Autor: |
Sugimoto, Takeshi, Saigo, Katsuyasu, Shin, Tomohiro, Kaneda, Yohji, Manabe, Nobuya, Narita, Hiroko, Wakuya, Jun, Imoto, Shion, Murayama, Tohru, Matsumoto, Masanori, Fujimura, Yoshihiro, Nishimura, Ryuichiro, Koizumi, Tamio, Kumagai, Shunichi |
| Předmět: |
|
| Zdroj: |
Acta Haematologica; 2005, Vol. 113 Issue 3, p198-203, 6p, 5 Color Photographs, 1 Chart, 1 Graph |
| Abstrakt: |
A 59-year-old woman, diagnosed with chronic myelogenous leukemia (chronic phase) and treated with interferon-α for 13 years, developed renal failure. Renal biopsy showed thrombotic thrombocytopenic purpura, but intensive therapy including plasma exchange and steroid administration was not effective. The activity of von Willebrand factor-cleaving protease was detectable at the intermediate level (15–46%) during the clinical course, suggesting that this case was not compatible with the previously reported pattern of idiopathic or drug-induced thrombotic thrombocytopenic purpura, but with the pattern associated with malignant disease or immunological disorders. Further studies to determine the effects of interferon-α on endothelial cells in chronic myelogenous leukemia patients are needed. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
