| Autor: |
Petru, Edgar, Pasterk, C., Reich, O., Obermair, A., Winter, R., Breitenecker, G. |
| Předmět: |
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| Zdroj: |
Archives of Gynecology & Obstetrics; Apr2005, Vol. 271 Issue 4, p316-319, 4p |
| Abstrakt: |
Background: Small cell carcinomas (small-C Cs) of the uterine cervix are rare and highly malignant neoplasms. Patients tend to develop distant metastasis early and thus are potential candidates for systemic therapy. We reviewed the experience with small-CCs of the uterus and vagina at two Austrian University hospitals. Material and methods: Ten patients (median age, 50 years; range, 18-92) with small-CC of the cervix (n 7), uterine corpus (n 2), and the vagina (n 1) were treated at the two centers between 1988 and 1998. Eight patients underwent radical surgery, 7 of whom also received chemotherapy. Two additional patients under- went primary radiotherapy. Results: All Pap smears were suspicious for cervical malignancy. The median survival was 12 months (range, 6-86) and overall 5-year survival was 10%. Five of 8 surgically treated patients had lymph node involvement (62%). Of the 7 patients with small-CC of the cervix only one, who had FIGO stage JIB disease and positive pelvic nodes, survived long-term (86 months) with no evidence of disease. She had received six courses of dose-intensive platinum chemotherapy after radical surgery. All three patients with small-CC of the uterine corpus or vagina developed recurrence within the first year after diagnosis. Of the 7 patients who received chemotherapy, 5 developed progressive or recurrent disease in the paraaortic region (n = 2), peritoneum (n = 1), liver (n = 1), or pelvis (n = 1). Conclusion: These results confirm the particularly unfavorable prognosis of patients with small-CC of the genital tract. The optimal treatment for these patients most probably including concurrent chemo-radiotherapy remains to be defined. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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