The effect of erythromycin on the pharmacokinetics of rosuvastatin.

Autor: Cooper, K. J., Martin, P. D., Dane, A. L., Warwick, M. J., Raza, A., Schneck, D. W.
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Zdroj: European Journal of Clinical Pharmacology; May2003, Vol. 59 Issue 1, p51-56, 6p
Abstrakt: Rationale. Objective. To examine in vivo the effect of erythromycin on the pharmacokinetics of rosuvastatin [an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase]. Erythromycin is a potent inhibitor of CYP3A4 that markedly increases circulating levels of some other HMG-CoA reductase inhibitors. Methods. In this randomised, double-blind, two-way cross-over, placebo-controlled trial 14 healthy volunteers were given 500 mg erythromycin or placebo four times daily for 7 days. A single dose of 80 mg rosuvastatin was co-administered on day 4 of dosing. Plasma concentrations of rosuvastatin and active and total HMG-CoA reductase inhibitors were measured up to 96 h after dosing. Results. Eleven volunteers had data available from both dosing periods. There was no increase in rosuvastatin plasma exposure following co-administration with erythromycin compared to placebo. In fact, following co-administration with erythromycin, rosuvastatin geometric least square mean AUC(0–t) and Cmax were 20% and 31%, respectively, lower than with placebo. Individual treatment ratios for AUC(0–t) ranged from 0.48 to 1.17, and for Cmax ranged from 0.33 to 2.19. Essentially all of the circulating active HMG-CoA reductase inhibitors and most (>94%) of the total inhibitors were accounted for by rosuvastatin. Erythromycin did not affect the proportion of circulating active or total inhibitors accounted for by circulating rosuvastatin. Conclusions. Erythromycin did not produce any increase in rosuvastatin plasma exposure. This indicates that CYP3A4 metabolism is not an important clearance mechanism for rosuvastatin, a result consistent with previous findings. The small decreases in rosuvastatin AUC(0–t) and Cmax that occurred as a consequence of short-term treatment with erythromycin are unlikely to have relevance to long-term treatment with rosuvastatin. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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