| Autor: |
Bondar, N. F., Isaenya, L. P., Skupskaya, R. V., Lakhvich, F. A. |
| Předmět: |
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| Zdroj: |
Russian Journal of Organic Chemistry; Aug2003, Vol. 39 Issue 8, p1095-1103, 9p |
| Abstrakt: |
Chemical transformations of 9,11-ethano-13,15-isoxazolinoprostanoids furnished new prostanoids with a bufunctional fragment of β-hydroxyketone and γ-aminoalcohol in the ω-chain. The reaction of β-hydroxyketones with methanesulfonyl chloride gave rise to prostanoids with an enone component in the ω-chain. 9,11-Ethano-16-thiaprostanoids were prepared for the first time by nucleophilic addition of thiols to the polarized double bond in the ω-chain. The 1,3-dipolar addition to terminal alkenes of nitrile oxides generated from nitromethylene derivatives of bicycloheptane provided 9,11-ethano-13,15-isoxazolinoprostanoids with an alkyl, phenyl, or additional heterocyclic fragment in the ω-chain. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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