| Autor: |
N. Leveque, P. Muret, S. Makki, S. Mac-Mary, J.P. Kantelip, P. Humbert |
| Předmět: |
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| Zdroj: |
Skin Pharmacology & Physiology; Nov2004, Vol. 17 Issue 6, p298-303, 6p |
| Abstrakt: |
Background: Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect the skin from these insults. Objective: The aim of this study was to determine the ex vivo ascorbic acid penetration and its degradation in the skin after its topical application from an 8% new formulation. Method: Ascorbic acid was applied to human skin fragments. Ascorbic acid and its metabolites were collected by microdialysis and assessed by gas chromatography mass spectrometry. Results: After topical application of the new formulation, the ascorbic acid level achieved was 8.5 times the normal tissue value. This high ascorbic acid dermal concentration remained constant if a topical application was made every 8 h. No degradation of ascorbic acid was detected. Conclusion: Ascorbic acid penetrates rapidly after its topical application. The persistent reservoir of ascorbic acid provides an important and attractive photoprotection strategy.Copyright © 2004 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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