Limitations of the Use of Intra-Arterial Fibrinolytic Agents in Acute Lower Limb Ischemia.

Autor: Corson, John D., Chang, Benjamin B., Goldman, Martin, Sarrafizadeh, Mohammad S., Leopold, Peter W., Leather, Robert P., Shah, Dhiraj M., Karmody, Allastair M.
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Zdroj: Vascular Surgery; Mar/Apr1986, Vol. 20 Issue 2, p105-111, 7p, 4 Charts
Abstrakt: The use of direct regional intraarterial low dose fibrinolytic therapy was retrospectively studied in a group of 25 patients with acute lower limb ischemia. Bleeding problems were minimized due to careful monitoring of fibrinogen levels. However two bleeding complications developed during lytic therapy on patients who had undergone recent surgical intervention. Following lysis a surgically correctable lesion was seen in one recently occluded conduit and in four late bypass occlusions. Eighty-three percent of the patients who had some lytic response required surgical intervention. The average time of fibrinolytic infusion was 46.7 hours. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index