| Autor: |
Morishita, Yasuo, Kawakami, Toshiaki, Arikawa, Kazuhiro, Hashiguchi, Masahiko, Harada, Taizo, Moriyama, Yukinori, Iguro, Yoshifumi, Taira, Akira, Sakamoto, Hiroto |
| Předmět: |
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| Zdroj: |
Vascular Surgery; Jan/Feb1990, Vol. 24 Issue 1, p1-6, 6p, 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 1 Chart |
| Abstrakt: |
Long-distance procurement of canine hearts following preservation by coronary perfusion was twice attempted by simple cooling under septic conditions. Following cardiac arrest by cardioplegia, the donor heart was excised and switched to a Langendorffs model. Continuous hypothermic, low-pressure coronary perfusion with a 4°C new modified Krebs solution was performed for seventeen hours. Thereafter, the graft was placed in a thermal (4°C) protected environment. In transportation of 2,124 km, automobiles and commercial airlines were used. The total transport and ischemic times were nine and twenty-seven hours, respectively. The myocardial temperature during both the preservation with coronary perfusion and the transportation by immersion was maintained at 5-7°C. After orthotopic transplantation, both grafts provided good support of the recipient circulation for six-hour and seven-hour observation periods. No contraction band injury was histologically observed in the myocardial cells, and the electron microscopic study also revealed almost normal features of the myocardial cells after transplantation. The present experience suggests that long-distance human heart procurement for transplantation may be safely performed using the conventionally available transportation system in Japan and that the donor heart can be viably stored for a long time (twenty-six hours) by the combination method of coronary perfusion and simple cooling. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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