| Autor: |
Hoover, Eddie L., Kharma, Bassam, Ross, Margery, Webb, Hueldine, Fani, Kazam, DiMaio, Frank, Ketosugbo, Anukware, Hwei-Kang Hsu |
| Předmět: |
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| Zdroj: |
Vascular Surgery; May/Jun1989, Vol. 23 Issue 3, p175-182, 8p, 1 Chart, 2 Graphs |
| Abstrakt: |
Using a canine model, the authors evaluated the effects of twenty-four hours of intraaortic balloon counterpulsation (IABCP) on the morphology of the thoracoabdominal aorta and its spontaneous and arachidonate stimulated production of prostacyclin (PGI2). The treated group was counter-pulsed at a 1:1 ratio with a 40 cc balloon. The control group had the balloon inserted and left deflated across the thoracoabdominal aorta. There were no differences between the IABCP or sham groups in prostanoid production either in the thoracic or abdominal aorta. Baseline PGI2 production in the control versus treated group of thoracic aortas was 1880 ± 1140 pg/cm² min vs 1992 ± 1125. The stimulated response in the control group, 9180 ± 1198, was statistically different from baseline (P < .001). The stimulated increase in the IABCP group, 6269 ± 5240, relative to baseline was also significant (P < .01). There were no significant differences, either between or within groups in the abdominal aortas. Poststimulation values (30 min) were significantly below baseline in each group in each section of the aorta (P < .05). Light microscopy showed a statistically significant difference in endothelial preservation between the control and the balloon group, 66 ± 25% vs 19 ± 17% (P < 0.05). The authors conclude that IABCP results in severe endothelial destruction but that spontaneous and stimulated PGI2 production is unimpaired. It remains to be determined whether the aorta may sustain long-term damage due to the repair process after IABCP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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