Preparation of 3β-Acetoxy-17a-Oxo-Androst-5-Ene-7,17-Dione, a Biologically Active Impurity Isolated from the Production of 3β-Acetoxyandrost-5-Ene-7,17-Dione.

Autor:	Coutts, LisaD., DeOrazio, RussellJ., Meckler, Harold
Předmět:	OXIDATION LACTONES ORGANIC cyclic compounds ACETATES CHEMISTRY
Zdroj:	Synthetic Communications; 2005, Vol. 35 Issue 7, p979-985, 7p
Abstrakt:	An impurity isolated during the kilo-lab preparation of 3β-acetoxyandrost-5-ene-7,17-dione was identified as 3β-acetoxy-17a-oxo-androst-5-ene-7,17-dione. This novel D-ring secosteroid was postulated to be a Baeyer-Villiger oxidation by-product of the preparation reaction. A genuine sample was prepared by the selective peracid-mediated Baeyer-Villiger reaction on 3β-acetoxyandrost-5-ene-7,17-dione (7-oxo-DHEA acetate), confirming the novel structure. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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