Green Stereoselective Synthesis and In Silico Anticancer Evaluation of Tetrahydro-β-carboline-Derived Spiro Heterocycles.

Autor:	Mohan, Maneesh, Eldhose, Susan P., Sudheendranath, Athul, G., Jayasree E., Deepthi, Ani
Předmět:	YLIDES RING formation (Chemistry) ISOQUINOLINE HETEROCYCLIC compounds MOLECULES
Zdroj:	Synthesis; Aug2023, Vol. 55 Issue 16, p2526-2536, 11p
Abstrakt:	SP 1 sp H NMR (400 MHz, CDCl SB 3 sb ): = 8.05-8.03 (m, 2 H), 7.66-7.63 (m, 1 H), 7.61-7.59 (m, 1 H), 7.51-7.48 (m, 2 H), 7.40-7.38 (m, 1 H), 7.26-7.22 (m, 2 H), 7.18-7.14 (td, I J i = 7.6. 0.8 Hz, 1 H), 7.04-6.97 (m, 5 H), 6.95-6.89 (m, 3 H), 6.67 (d, I J i = 7.6 Hz, 1 H), 5.86 (d, I J i = 9.2 Hz, 1 H), 5.16 (uneven t, I J i =8.6 Hz, 1 H), 4.48 (d, I J i = 8 Hz, 1 H), 2.94-2.84 (m, 3 H), 2.63-2.59 (m, 1 H), 2.19 (s, 3 H). SP 1 sp H NMR (400 MHz, CDCl SB 3 sb ): = 7.95 (d, I J i = 2 Hz, 2 H), 7.63-7.58 (m, 2 H), 7.42-7.40 (m, 1 H), 7.29-7.27 (m, 1 H), 7.19-7.14 (m, 1 H), 7.10-6.98 (m, 10 H), 6.70 (d, I J i = 7.6 Hz, 1 H), 5.86 (d, I J i =9.2 Hz, 1 H), 4.99 (t, I J i = 8.8 Hz, 1 H), 4.38 (d, I J i = 8.4 Hz, 1 H), 2.95-2.88 (m, 3 H), 2.67-2.64 (m, 1 H). SP 1 sp H NMR (400 MHz, CDCl SB 3 sb ): = 8.05 (d, I J i = 7.2 Hz, 2 H), 7.66-7.59 (m, 3 H), 7.57-7.50 (m, 3 H), 7.41-7.38 (m, 2 H), 7.29-7.14 (m, 5 H), 6.97-6.92 (m, 3 H), 6.69 (d, I J i = 7.6 Hz, 1 H), 5.85 (d, I J i = 8.8 Hz, 1 H), 5.14 (t, I J i = 8.8 Hz, 1 H, CH), 4.45 (d, I J i = 8.4 Hz, 1 H), 2.94-2.85 (m, 3 H), 2.62-2.60 (m, 1 H). [Extracted from the article]
Databáze:	Complementary Index
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