| Abstrakt: |
Background: Heart attacks and cardiac deaths have become so common nowadays that when an elderly individual succumbs, it gets little attention as it seems natural and an inevitable. As in all populations, conventional risk factors are significantly associated with the risk of coronary artery disease in Indians. Objectives: this study was conducted to evaluate conventional risk factors with premature coronary artery disease by analyzing the levels of HbA1c, lipoproteins and triglycerides in premature coronary artery disease. Methods: We studied 90 patients of either gender who underwent angiography. study population was analyzed in three stages namely; their demographical representation in accordance with risk factors, presence and type of angiographic findings, case control type analysis to prove independent significance of risk factors with relation to CAD and analysis of risk factors as per the angiographic finding in terms of severity. Weight, BMI, HbA1c, systolic blood pressure, diastolic blood pressure, pulse, LDL, VLDL, HDL, total cholesterol, and triglyceride were calculated. Result: Mean age in cases was 50±7.3 years and of controls was 51±6.3 years with Male preponderance [3.5:1]. Most frequent conventional risk factors present in total study sample were hypertension (53%), diabetes (50%), dyslipidemia(41%), family history (32%), alcohol use(43%), tobacco use(38%); while in cases of CAD they were hypertension (73%), diabetes (75%), dyslipidemia(62%), family history(49%), alcohol use(60%), tobacco use(53%). Statistically significant risk factors were BMI, HbA1c, triglycerides, LDL, and total cholesterol. dyslipidemia was correlated 20% to CAD progression as well as severity. Conclusion: Our study also proves multi factorial causation of CAD with lesser number of risk factors present in controls and higher number of risk factors in cases. 8 risk factors were present in 2% whereas 31 % cases showed presence of 6. [ABSTRACT FROM AUTHOR] |
